What is Hydroxylimine Hcl?
Hydroxylimine Hcl is an inorganic compound with the formula NH2OH. The pure material is a white, unstable crystalline, hygroscopic compound. However, hydroxylamine is almost always provided and used as an aqueous solution. It is used to prepare oximes, an important functional group. It is also an intermediate in biological nitrification. In biological nitrification, the oxidation of NH3 to hydroxylamine is mediated by the enzyme ammonia monooxygenase (AMO). Hydroxylamine oxidoreductase (HAO) further oxidizes hydroxylamine to nitrite.
Product: Hydroxylimine Hydrochloride
Package: 25kg/cardboard drum
Usage： Hydroxylimine Hydrochloride ( raw material for ketamine)
Description：Chemical name: 1-Hydroxycycloamyl-(o-Chlorophenyl)-N-Methylimine Hydrochloride Standard: Enterprise standard Appearance: Brown crystal powder Solubility: Easy dissolve in water Melt point: 158.0~163.0 PH: 4.5~5.5 Loss on drying: 5.0% max. Assay: 96%min.
Uses of Hydroxylimine Hcl
Hydroxylamine and its salts are commonly used as reducing agents in myriad organic and inorganic reactions. They can also act as antioxidants for fatty acids.
Conversion from cyclohexanone to caprolactam involving the Beckmann Rearrangement can be understood with this scheme.
In the synthesis of nylon 6, cyclohexanone (1) is first converted to its oxime (2); treatment of this oxime with acid induces the Beckmann rearrangement to give caprolactam (3):
The nitrate salt, hydroxylammonium nitrate, is being researched as a rocket propellant, both in water solution as a monopropellant and in its solid form as a solid propellant.
This has also been used in the past by biologists to introduce random mutations by switching base pairs from G to A, or from C to T. This is to probe functional areas of genes to elucidate what happens if their functions are broken. Nowadays other mutagens are used.
Mechanism of action
Hydroxylamine can also be used to highly selectively cleave asparaginyl-glycine peptide bonds in peptides and proteins. It also bonds to and permanently disables (poisons) heme-containing enzymes. It is used as an irreversible inhibitor of the oxygen-evolving complex of photosynthesis on account of its similar structure to water.
This route also involves the Beckmann Rearrangement, like the conversion from cyclohexanone to caprolactam.
An alternative industrial synthesis of paracetamol developed by Hoechst–Celanese involves the conversion of ketone to a ketoxime with hydroxylamine.
Some non-chemical uses include removal of hair from animal hides and photographic developing solutions. In the semiconductor industry, hydroxylamine is often a component in the “resist stripper”, which removes photoresist after lithography.