Description and history of ALD-53
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Firstly, it is possible ALD-52 was the active chemical in the Orange Sunshine variety of LSD. Secondly, that was widely available in California through 1968 and 1969. The Sonoma County underground chemistry lab of Tim Scully and Nicholas Sand was Orange Sunshine’s source. It was shut down by the police, and Scully was arrested and prosecuted. This resulted in the first drug analogue trial, where Scully claimed that he and his partners did nothing illegal, because they were producing ALD-52, which was not an illicit drug. However, as the prosecution claimed, there were problems with such a rationale—ALD-52 was claimed to readily undergo hydrolysis to LSD, and secondly, the synthesis of ALD-52 required LSD. (The second point was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.
Effects of ALD-52
In Entry 26 of his compendium TiHKAL, which discussed LSD, Shulgin touched briefly on the subject of ALD-52. His writings are vague second hand accounts saying doses in the 50–175 µg range have resulted in various conclusions. One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent. Another informant claimed it was more effective in increasing blood pressure. Yet another informant could not tell them apart.
In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the “antiserotonin” effect as compared with LSD. Human experiments have not been well documented.