What is 4-AcO-EiPT?
Chemistry of 4-AcO-EiPT.
O-Acetylpsilocin can be obtained by acetylation of psilocin under alkaline or strongly acidic conditions. It is, therefore, a semi-synthetic compound. It is believed to be a prodrug of psilocin, however, speculation that psilacetin may itself also be active exists. O-Acetylpsilocin is more resistant than psilocin to oxidation under basic conditions due to its acetoxy group. While O-acetylpsilocin is not well researched (sometimes viewed negatively as a research chemical, as opposed to psilocin and psilocybin). Though it is not as difficult to produce as psilocybin. Due to their similar mechanism of action, this may further support ideas of O-acetylpsilocin possibly serving as an appropriate substitute to psilocybin. For use in research of the effects psychedelic compounds in medicine.
In the body O-acetylpsilocin is deacetylated to psilocin by deacetylases/acetyltransferases during first pass metabolism and during subsequent passes through the liver (evident as psilacetin is also active via parenteral routes of ingestion).
Claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin differ: some users report that O-acetylpsilocin lasts slightly longer while others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by O-acetylpsilocin more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if psilacetin is active itself and not merely as a prodrug. Despite this, there have been no controlled clinical studies to distinguish any effects of psilacetin, psilocin, and psilocybin from one another.