What is 2-Phenylethylamine Hydrochloride?
PEA is an endogenous neurotransmitter and neuroregulator that plays a key role in mood and cognition. It is associated with states of heightened arousal, euphoria, and excitation, as well as increased attention and concentration.
Mechanisms of action of 2-Phenylethylamine Hydrochloride
- Stimulates dopamine, norepinephrine, and acetylcholine levels.
- Modulates receptor sensitivity and reuptake processes.
- Synthesized in the body from the amino acid phenylalanine.
- Psychoactive ingredient in chocolate and blue green algae.
- Synergistic with MAO-B inhibitors like Hordenine.
- Phenylethylamines are a category of empathogens and entheogens derived from PEA and that act largely on its receptor sites
What are the side effects of 2-Phenylethylamine Hydrochloride?
D-phenylalanine (but not L-phenylalanine) has been proposed to treat chronic pain. Two studies that appeared to show positive results had flaws that made the findings unreliable. Other studies have found D-phenylalanine to be no more effective than placebo in reducing pain. No randomized controlled trials have been done in the past 20 years to study any possible benefit of taking D-phenylalanine for chronic pain. More research is needed to determine its safety and effectiveness.
One animal study suggests that D-phenylalanine may improve rigidity, walking disabilities, speech difficulties, and depression associated with Parkinson disease. However, there is no evidence yet whether it would have the same effect in humans. More research is needed.